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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Oxaliplatin (Code C65110)

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Terms & Properties

Preferred Name: Liposomal Oxaliplatin

Definition: The liposomal preparation of oxaliplatin, an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group'. A leaving group is an atom or a group of atoms that is displaced as a stable species taking with it its bonding electrons. After displacement of the labile oxalate ligand leaving group, the active oxaliplatin derivatives (monoaquo and diaquo DACH platinum) alkylate macromolecules, and form both inter- and intra-strand platinum-DNA crosslinks, thereby inhibiting DNA replication and resulting in cytotoxicity. The DACH side chain appears to inhibit DNA repair mechanism, therefore overcoming the limits observed in other platinum-based therapies.

Label: Liposomal Oxaliplatin

NCI Thesaurus Code: C65110 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831940  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposomal Oxaliplatin
Lipoxal

External Source Codes: 
PDQ Closed Trial Search ID 500373
PDQ Open Trial Search ID 500373 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831940

Other Properties:
     Name Value (qualifiers indented underneath)
code C65110
Legacy_Concept_Name Liposomal_Oxaliplatin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C65110

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