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Version: 16.11d (Release date: 2016-11-28)
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Metoclopramide Hydrochloride (Code C649)

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Terms & Properties

Preferred Name: Metoclopramide Hydrochloride

Definition: The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.

NCI-GLOSS Definition: A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent.

Label: Metoclopramide Hydrochloride

NCI Thesaurus Code: C649 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0887128  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
METOCLOPRAMIDE HYDROCHLORIDE
Metoclopramide Hydrochloride
Reglan

External Source Codes: 
CAS Registry Number 7232-21-5 (see NLM ChemIDplus info)
FDA UNII Code W1792A2RVD
ChEBI ID CHEBI:6899 (see ChEBI info)
NSC Code 354467 (see NCI DTP info)
PDQ Closed Trial Search ID 39502
PDQ Open Trial Search ID 39502 (check for NCI PDQ open clinical trial info)
UMLS CUI C0887128

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C14H22ClN3O2.HCl.H2O
code C649
Contributing_Source FDA
Legacy_Concept_Name Metoclopramide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C649

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