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Version: 17.06d (Release date: 2017-06-26)
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Alpha-type-1 Polarized Dendritic Cells (Code C64846)

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Terms & Properties

Preferred Name: Alpha-type-1 Polarized Dendritic Cells

Definition: A mature polarized dendritic cell with potent immunostimulating activity. Treating dendritic cells (DCs) with interferon-alpha (IFN-a) and polyinosinic:polycytidylic acid (p-I:C) in addition to a cytokine cocktail (tumor necrosis factor alpha/Interleukin-1beta/IFN-gamma) produces mature but not exhausted alpha type-1 polarized DCs (alphaDC1) that are capable of: 1) high responsiveness to other lymphoid chemokines, and 2) producing high level of interleukin-12p70 (IL-12p70). Therefore, alphaDC1 has a much more significant capability of inducing helper T cell (CD4+ T-cell) responses in comparison with the "gold standard" DCs. When pulsed with specific tumor associated antigens (TAAs), alphaDC1 is able to induce a potent cytotoxic T lymphocyte (CTL) response against TAAs; as a result it can be used as a cancer vaccine.

Display Name: Alpha-type-1 Polarized Dendritic Cells

Label: Alpha-type-1 Polarized Dendritic Cells

NCI Thesaurus Code: C64846 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831973  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-type-1 Polarized Dendritic Cells
alphaDC1

External Source Codes: 
PDQ Closed Trial Search ID 513178
PDQ Open Trial Search ID 513178 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831973

Other Properties:
     Name Value (qualifiers indented underneath)
code C64846
Contributing_Source CTRP
Legacy_Concept_Name Alpha-Type-1_Polarized_Dendritic_Cell
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64846

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