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Version: 17.06d (Release date: 2017-06-26)
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AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine (Code C64785)

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Terms & Properties

Preferred Name: AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine

Definition: A cell-based vaccine comprised of prostate cancer cells transduced with an adenoviral vector encoding human RTVP-1 (AdRTVP-1), with potential antineoplastic and immunostimulating activities. RTVP-1, also referred to as glioma pathogenesis-related protein 1 (GLIP1), is down-regulated in prostate tumors. Regulated by tumor suppressor p53, the expression of RTVP-1 functions as a tumor suppressor, and is abundant in normal human prostate epithelial cells as well as in differentiated macrophages. Administration of this vaccine leads to an induction of apoptosis through the expression of RTVP-1 and results in a reduction in cellular proliferation in prostate cancer cells. In addition, this cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against prostate specific tumor associated antigens, resulting in an immune-mediated prostate cancer cell death. Furthermore, RTVP-1 stimulates CTL and natural killer (NK) cell activities.

Display Name: AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine

Label: AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine

NCI Thesaurus Code: C64785 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832007  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenoviral Vector-Mediated RTVP-1 Gene-modified Prostate Cancer Cell-based Vaccine
AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 526815
PDQ Open Trial Search ID 526815 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832007

Other Properties:
     Name Value (qualifiers indented underneath)
code C64785
Contributing_Source CTRP
Legacy_Concept_Name AdRTVP-1-Transduced_Prostate_Cancer_Cell-Based_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64785

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