|DACH Polymer Platinate AP5346 (Code C64784)|
|Terms & Properties|
Preferred Name: DACH Polymer Platinate AP5346
Definition: A low molecular weight polymer-conjugated platinum complex with potential antineoplastic activity. This polymer drug delivery system consists of cytotoxic diaminocyclohexane (DACH)-platinum (Pt) coupled to a water-soluble biocompatible hydroxypropylmethacrylamide (HPMA) copolymer via a pH sensitive linker. Due to decreased pH at the tumor site, the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor cells. DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA crosslinks, which impede DNA replication and transcription, thereby resulting in cell-cycle independent cytotoxicity. The HPMA-based drug delivery system enhances the concentration of DACH-Pt at the tumor site and prolongs the half life of the agent, thereby increasing exposure and efficacy at the target tumor sites while minimizing side effects in normal tissues.
NCI-GLOSS Definition: A substance being studied in the treatment of head and neck cancer. It may kill cancer cells by carrying an anticancer drug into the tumor. It is a type of platinum compound.
Label: DACH Polymer Platinate AP5346
NCI Metathesaurus Link: C1723251 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|DACH Polymer Platinate AP5346|
External Source Codes:
|PDQ Closed Trial Search ID||526175|
|PDQ Open Trial Search ID||526175 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|