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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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DACH Polymer Platinate AP5346 (Code C64784)

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Terms & Properties

Preferred Name: DACH Polymer Platinate AP5346

Definition: A low molecular weight polymer-conjugated platinum complex with potential antineoplastic activity. This polymer drug delivery system consists of cytotoxic diaminocyclohexane (DACH)-platinum (Pt) coupled to a water-soluble biocompatible hydroxypropylmethacrylamide (HPMA) copolymer via a pH sensitive linker. Due to decreased pH at the tumor site, the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor cells. DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA crosslinks, which impede DNA replication and transcription, thereby resulting in cell-cycle independent cytotoxicity. The HPMA-based drug delivery system enhances the concentration of DACH-Pt at the tumor site and prolongs the half life of the agent, thereby increasing exposure and efficacy at the target tumor sites while minimizing side effects in normal tissues.

NCI-GLOSS Definition: A substance being studied in the treatment of head and neck cancer. It may kill cancer cells by carrying an anticancer drug into the tumor. It is a type of platinum compound.

Label: DACH Polymer Platinate AP5346

NCI Thesaurus Code: C64784 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1723251  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DACH Polymer Platinate AP5346

External Source Codes: 
PDQ Closed Trial Search ID 526175
PDQ Open Trial Search ID 526175 (check for NCI PDQ open clinical trial info)
UMLS CUI C1723251

Other Properties:
     Name Value (qualifiers indented underneath)
code C64784
Legacy_Concept_Name DACH_Polymer_Platinate_AP5346
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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