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Version: 17.06d (Release date: 2017-06-26)
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Verubulin Hydrochloride (Code C64782)

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Terms & Properties

Preferred Name: Verubulin Hydrochloride

Definition: The hydrochloride salt form of verubulin, a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), verubulin appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.

Display Name: Verubulin Hydrochloride

Label: Verubulin Hydrochloride

NCI Thesaurus Code: C64782 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832001  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Microtubule Inhibitor MPC-6827
N-(4-methoxyphenyl)-n,2-dimethylquinazolin-4-amine Hydrochloride
Verubulin Hydrochloride

External Source Codes: 
CAS Registry Number 917369-31-4 (see NLM ChemIDplus info)
FDA UNII Code 33380QZ0QW
PDQ Closed Trial Search ID 526176
PDQ Open Trial Search ID 526176 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832001

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H17N3O.HCl
code C64782
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MPC-6827
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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