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Version: 17.06d (Release date: 2017-06-26)
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Navitoclax (Code C64776)

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Terms & Properties

Preferred Name: Navitoclax

Definition: An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation.

NCI-GLOSS Definition: A substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying. It is a type of Bcl-2 family inhibitor.

Display Name: Navitoclax

Label: Navitoclax

NCI Thesaurus Code: C64776 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2975395  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BcI-2 Family Protein Inhibitor ABT-263

External Source Codes: 
CAS Registry Number 923564-51-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 523413
PDQ Open Trial Search ID 523413 (check for NCI PDQ open clinical trial info)
UMLS CUI C2975395

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C47H55ClF3N5O6S3
code C64776
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ABT-263
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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