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Version: 16.11d (Release date: 2016-11-28)
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Carcinoembryonic Antigen-Expressing Measles Virus (Code C64775)

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Terms & Properties

Preferred Name: Carcinoembryonic Antigen-Expressing Measles Virus

Definition: An attenuated oncolytic Edmonston (Ed) strain of measles virus (MV) encoding the soluble extracellular N-terminal domain of human carcinoembryonic antigen (CEA) (MV-CEA) with potential antineoplastic activity. The cellular receptor of MV is human CD46 antigen, a type 1 integral membrane glycoprotein found on nearly all human tissues and overexpressed on many cancer cell types. Mediated through CD46, both haemagglutinin and fusion glycoproteins of MV are required for the attachment to and fusion of host cell membranes, thereby leading to syncytia and cell lysis. The expressed CEA, a tumor associated antigen, can be detected in serum and used as a sensitive marker to monitor viral gene expression in order to easily optimize individual therapy. Compared to wild-type MV, the Ed strain of MV has a lower affinity for the MV receptor signaling lymphocyte-activation molecule (CD150), mainly expressed in B- and T-lymphocytes, but a higher affinity for CD46.

Display Name: Carcinoembryonic Antigen-Expressing Measles Virus

Label: Carcinoembryonic Antigen-Expressing Measles Virus

NCI Thesaurus Code: C64775 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831991  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carcinoembryonic Antigen-Expressing Measles Virus
MV-CEA

External Source Codes: 
PDQ Closed Trial Search ID 523412
PDQ Open Trial Search ID 523412 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831991

Other Properties:
Name Value (qualifiers indented underneath)
code C64775
Contributing_Source CTRP
Legacy_Concept_Name Carcinoembryonic_Antigen-Expressing_Measles_Virus
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64775

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