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Version: 17.06d (Release date: 2017-06-26)
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Tenifatecan (Code C64772)

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Terms & Properties

Preferred Name: Tenifatecan

Definition: A highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and triggers programmed cell death. SN2310 emulsion provides longer circulation time and potentiates drug exposure as compared to the unconjugated SN-38.

Label: Tenifatecan

NCI Thesaurus Code: C64772 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1883354  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin- 9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl Butanedioate
Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin

External Source Codes: 
CAS Registry Number 850728-18-6 (see NLM ChemIDplus info)
FDA UNII Code 7G0Y719Q80
PDQ Closed Trial Search ID 518315
PDQ Open Trial Search ID 518315 (check for NCI PDQ open clinical trial info)
UMLS CUI C1883354

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C55H72N2O9
code C64772
Contributing_Source FDA
Legacy_Concept_Name Tocopherol_Succinate_7-Ethyl-10-Hydroxycamptothecin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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