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Version: 17.06d (Release date: 2017-06-26)
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E2F1 Pathway Activator ARQ 171 (Code C64767)

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Terms & Properties

Preferred Name: E2F1 Pathway Activator ARQ 171

Definition: A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression.

Label: E2F1 Pathway Activator ARQ 171

NCI Thesaurus Code: C64767 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832018  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARQ 171
E2F1 Pathway Activator ARQ 171

External Source Codes: 
PDQ Closed Trial Search ID 529342
PDQ Open Trial Search ID 529342 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832018

Other Properties:
     Name Value (qualifiers indented underneath)
code C64767
Legacy_Concept_Name ARQ_171
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64767

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