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Version: 17.06d (Release date: 2017-06-26)
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Efatutazone Dihydrochloride (Code C64764)

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Terms & Properties

Preferred Name: Efatutazone Dihydrochloride

Definition: The dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.

Display Name: Efatutazone Dihydrochloride

Label: Efatutazone Dihydrochloride

NCI Thesaurus Code: C64764 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1721778  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4-thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1h-benzimidazol-2-yl)methoxy)phenyl)methyl)-, Hydrochloride (1:2)
Efatutazone Dihydrochloride
Inolitazone Dihydrochloride

External Source Codes: 
CAS Registry Number 223132-38-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 529846
PDQ Open Trial Search ID 529846 (check for NCI PDQ open clinical trial info)
UMLS CUI C1721778

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H26N4O4S.2ClH
code C64764
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CS-7017
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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