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Version: 17.06d (Release date: 2017-06-26)
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Efatutazone Dihydrochloride (Code C64764)

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Terms & Properties

Preferred Name: Efatutazone Dihydrochloride

Definition: The dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.

Display Name: Efatutazone Dihydrochloride

Label: Efatutazone Dihydrochloride

NCI Thesaurus Code: C64764 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1721778  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4-thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1h-benzimidazol-2-yl)methoxy)phenyl)methyl)-, Hydrochloride (1:2)
CS-7017
Efatutazone Dihydrochloride
EFATUTAZONE DIHYDROCHLORIDE
Inolitazone Dihydrochloride

External Source Codes: 
CAS Registry Number 223132-38-5 (see NLM ChemIDplus info)
FDA UNII Code 76B44WEA8O
PDQ Closed Trial Search ID 529846
PDQ Open Trial Search ID 529846 (check for NCI PDQ open clinical trial info)
UMLS CUI C1721778

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H26N4O4S.2ClH
code C64764
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CS-7017
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64764

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