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Version: 17.12d (Release date: 2017-12-26)
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Fermented Wheat Germ Extract (Code C64763)

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Terms & Properties

Preferred Name: Fermented Wheat Germ Extract

Definition: An extract of fermented wheat germ containing a concentrated, standardized amount of methoxy-substituted benzoquinones with immunomodulatory and potential antineoplastic activities. Fermented wheat germ extract (FWGE) inhibits the activities of several enzymes involved in de novo nucleic acid synthesis and in supplying the dNTP pool required for DNA replication. This agent also induces caspase-3- mediated inactivation of poly(ADP)ribose polymerase (PARP), a key enzyme in DNA repair that is overexpressed in many cancers; cleavage of PARP prevents DNA repair and induces apoptosis. The benzoquinones may contribute to the immunomodulatory effects of FWGE, down-regulating major histocompatibility complex class I (MHC-1) protein on the surface of cancer cells, allowing natural killer (NK) cell surveillance; and up-regulating the expression of intracellular adhesion molecule 1 (ICAM-1) on tumor endothelial cells.

Label: Fermented Wheat Germ Extract

NCI Thesaurus Code: C64763 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0756278  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fermented Wheat Germ Extract

External Source Codes: 
PDQ Closed Trial Search ID 529839
PDQ Open Trial Search ID 529839 (check for NCI PDQ open clinical trial info)
UMLS CUI C0756278

Other Properties:
     Name Value (qualifiers indented underneath)
code C64763
Legacy_Concept_Name Fermented_Wheat_Germ_Extract
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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