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Version: 17.06d (Release date: 2017-06-26)
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Methylprednisolone (Code C647)

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Terms & Properties

Preferred Name: Methylprednisolone

Definition: A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.

NCI-GLOSS Definition: A corticosteroid hormone replacement.

Display Name: Methylprednisolone

Label: Methylprednisolone

NCI Thesaurus Code: C647 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025815  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
6Alpha-Methylprednisolone
Adlone
Caberdelta M
DepMedalone
Depo-Nisolone
Depo Moderin
Duralone
Emmetipi
Esametone
Firmacort
Medlone 21
Medrate
Medrol
Medrol Veriderm
Medrone
Mega-Star
Meprolone
Methylprednisolone
METHYLPREDNISOLONE
methylprednisolone
Methylprednisolonum
Metilbetasone Solubile
Metrocort
Metypresol
Metysolon
Predni-M-Tablinen
Prednilen
Radilem
Sieropresol
Solpredone
Summicort
Urbason
Veriderm Medrol
Wyacort

External Source Codes: 
CAS Registry Number 83-43-2 (see NLM ChemIDplus info)
FDA UNII Code X4W7ZR7023
ChEBI ID CHEBI:6888 (see ChEBI info)
NSC Code 19987 (see NCI DTP info)
PDQ Closed Trial Search ID 41528
PDQ Open Trial Search ID 41528 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025815

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Adrenocortical insufficiency; Conditions requiring immunosuppression; Inflammatory conditions; Multiple Sclerosis; Nephrotic syndrome
Chemical_Formula C22H30O5
code C647
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methylprednisolone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C647

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