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Version: 17.06d (Release date: 2017-06-26)
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Marizomib (Code C64634)

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Terms & Properties

Preferred Name: Marizomib

Definition: A naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity. Marizomib irreversibly binds to and inhibits the 20S catalytic core subunit of the proteasome by covalently modifying its active site threonine residues; inhibition of ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. This agent more may more potent and selective than the proteasome inhibitor bortezomib.

Display Name: Marizomib

Label: Marizomib

NCI Thesaurus Code: C64634 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1259854  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1R,4R,5S)-4-(2-chloroethyl)-1-{(S)-[(1S)-cyclohex-2-en-1-yl]hydroxymethyl}-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Marizomib
MARIZOMIB
ML 858
NPI-0052
Salinosporamide A
Salinosporin A

External Source Codes: 
CAS Registry Number 437742-34-2 (see NLM ChemIDplus info)
FDA UNII Code 703P9YDP7F
ChEBI ID CHEBI:48045 (see ChEBI info)
PDQ Closed Trial Search ID 518316
PDQ Open Trial Search ID 518316 (check for NCI PDQ open clinical trial info)
UMLS CUI C1259854

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H20ClNO4
code C64634
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name NPI-0052
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64634

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