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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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ZYC300 (Code C64631)

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Terms & Properties

Preferred Name: ZYC300

Definition: A formulation of a plasmid DNA encoding an inactivated form of the carcinogen activator cytochrome P450 1B1 (CYP1B1) encapsulated in biodegradable poly-DL-lactide-coglycolide microparticles with potential antineoplastic activity. CYP1B1, an extrahepatic monooxygenase of the cytochrome P450 family, is overexpressed in many cancers with only restricted expression in normal tissues. Vaccination with ZYC300 may stimulate the immune system to elicit a cytotoxic T lymphocyte (CTL) response against the tumor associated antigen CYP1B1, thereby causing lysis of tumor cells expressing CYP1B1.

Label: ZYC300

NCI Thesaurus Code: C64631 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831967  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 513166
PDQ Open Trial Search ID 513166 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831967

Other Properties:
     Name Value (qualifiers indented underneath)
code C64631
Legacy_Concept_Name ZYC300
Semantic_Type Gene or Genome
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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