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Version: 17.06d (Release date: 2017-06-26)
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EGFR/HER2 Inhibitor AV-412 (Code C64627)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: EGFR/HER2 Inhibitor AV-412

Definition: A second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.

Display Name: EGFR/HER2 Inhibitor AV-412

Label: EGFR/HER2 Inhibitor AV-412

NCI Thesaurus Code: C64627 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831968  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AV-412
EGFR/HER2 Inhibitor AV-412
MP-412

External Source Codes: 
PDQ Closed Trial Search ID 513167
PDQ Open Trial Search ID 513167 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831968

Other Properties:
     Name Value (qualifiers indented underneath)
code C64627
Contributing_Source CTRP
Legacy_Concept_Name AV-412
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64627

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