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Version: 16.11d (Release date: 2016-11-28)
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Isavuconazole (Code C64543)

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Terms & Properties

Preferred Name: Isavuconazole

Definition: A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and is hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements. This ultimately causes fungal cell lysis and death.

Display Name: Isavuconazole

Label: Isavuconazole

NCI Thesaurus Code: C64543 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832021  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAL8557
Isavuconazole
ISAVUCONAZOLE

External Source Codes: 
CAS Registry Number 241479-67-4 (see NLM ChemIDplus info)
FDA UNII Code 60UTO373KE
PDQ Closed Trial Search ID 529357
PDQ Open Trial Search ID 529357 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832021

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H17F2N5OS
code C64543
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Isavuconazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64543

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