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Version: 17.06d (Release date: 2017-06-26)
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Sapacitabine (Code C64541)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sapacitabine

Definition: An orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well.

Display Name: Sapacitabine

Label: Sapacitabine

NCI Thesaurus Code: C64541 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0764827  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CS-682
CYC682
N-(1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidin-4-yl)-hexadecanamide
Sapacitabine
SAPACITABINE

External Source Codes: 
CAS Registry Number 151823-14-2 (see NLM ChemIDplus info)
FDA UNII Code W335P73C3L
PDQ Closed Trial Search ID 513165
PDQ Open Trial Search ID 513165 (check for NCI PDQ open clinical trial info)
UMLS CUI C0764827

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H42N4O5
code C64541
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sapacitabine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64541

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