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Version: 17.12d (Release date: 2017-12-26)
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Cenisertib (Code C64540)

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Terms & Properties

Preferred Name: Cenisertib

Definition: A water-soluble, synthetic small molecule with potential antineoplastic activity. Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer. Inhibition of aurora kinases inhibits cell division and proliferation and induces apoptosis in tumor cells overexpressing AKs.

Display Name: Cenisertib

Label: Cenisertib

NCI Thesaurus Code: C64540 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3853900  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aurora Kinase Inhibitor AS703569

External Source Codes: 
CAS Registry Number 871357-89-0 (see NLM ChemIDplus info)
FDA UNII Code 5277GPA358
PDQ Closed Trial Search ID 522734
PDQ Open Trial Search ID 522734 (check for NCI PDQ open clinical trial info)
UMLS CUI C3853900

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H30FN7O
code C64540
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name R763
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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