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Version: 16.10e (Release date: 2016-10-31)
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KSP Inhibitor AZD4877 (Code C64522)

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Terms & Properties

Preferred Name: KSP Inhibitor AZD4877

Definition: A synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. Inhibition of KSP results in an inhibition of mitotic spindle assembly, activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, thereby causing cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, AZD4877 may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents.

Display Name: KSP Inhibitor AZD4877

Label: KSP Inhibitor AZD4877

NCI Thesaurus Code: C64522 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879525  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD4877
KSP Inhibitor AZD4877

External Source Codes: 
PDQ Closed Trial Search ID 522717
PDQ Open Trial Search ID 522717 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879525

Other Properties:
Name Value (qualifiers indented underneath)
code C64522
Contributing_Source CTRP
Legacy_Concept_Name AZD4877
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64522

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