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Version: 17.12d (Release date: 2017-12-26)
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Methylene Blue (Code C644)

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Terms & Properties

Preferred Name: Methylene Blue

Definition: A synthetic basic dye. Methylene blue stains to negatively charged cell components like nucleic acids; when administered in the lymphatic bed of a tumor during oncologic surgery, methylene blue may stain lymph nodes draining from the tumor, thereby aiding in the visual localization of tumor sentinel lymph nodes. When administered intravenously in low doses, this agent may convert methemoglobin to hemoglobin.

Display Name: Methylene Blue

Label: Methylene Blue

NCI Thesaurus Code: C644 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025746  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Azul de Metileno
Azul Metile
Blu di Metilene
CI Basic Blue 9
Colour Index No. 52015
Methylene Blue
Methylene blue
Methylenum Caeruleum
Methylthioninii Chloridum
Methylthioninium Chloride
Methylthioninium chloride
Schultz No. 1038
Tetramethylthionine Chloride Trihydrate
Urolene Blue

External Source Codes: 
CAS Registry Number 7220-79-3 (see NLM ChemIDplus info)
FDA UNII Code T42P99266K
ChEBI ID CHEBI:6872 (see ChEBI info)
NSC Code 617593 (see NCI DTP info)
PDQ Closed Trial Search ID 41780
PDQ Open Trial Search ID 41780 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025746

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cyanide poisoning, antidote; Diagnostic, indicator dye; Genitourinary antiseptic; Glutaricaciduria; Methemoglobinemia; Oxalate and phosphate urinary tract calculi, management
Chemical_Formula C16H18N3S.Cl.3H2O
code C644
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methylene_Blue
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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