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Version: 17.06d (Release date: 2017-06-26)
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Oral Fludarabine Phosphate (Code C64338)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Fludarabine Phosphate

Definition: An oral formulation of the phosphate salt of fludarabine, a synthetic purine nucleoside analogue antimetabolite with antineoplastic activity. Fudarabine is preferentially transported into malignant cells and metabolized by deoxycytidine kinase to its active form, 2-fluoro-ara-ATP; 2-fluoro-ara-ATP competes directly with deoxyadenosine triphosphate (dATP) and inhibits alpha DNA polymerase, RNA reductase, and DNA primase, which may result in inhibition of DNA synthesis and cell death.

Label: Oral Fludarabine Phosphate

NCI Thesaurus Code: C64338 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831839  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fludara Oral
Oral Fludarabine Phosphate

External Source Codes: 
PDQ Closed Trial Search ID 486428
PDQ Open Trial Search ID 486428 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831839

Other Properties:
     Name Value (qualifiers indented underneath)
code C64338
Legacy_Concept_Name Oral_Fludarabine_Phosphate
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64338

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