skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Methoxsalen (Code C643)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Methoxsalen

Definition: A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)

NCI-GLOSS Definition: A drug used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. It is also being studied in the treatment of graft-versus-host disease. It belongs to the family of drugs called psoralens and furocoumarins.

Display Name: Methoxsalen

Label: Methoxsalen

NCI Thesaurus Code: C643 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025684  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
8-Methoxypsoralen
8-MOP
9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one
Ammoidin
Deltasoralen
Dermox
Geralen
Geroxalen
Meladinina
Meladinine
Methoxsalen
METHOXSALEN
methoxsalen
Methoxypsoralen
Metoxaleno
Mopsoralen
Oxsoralen
Oxsoralen-Ultra
Puvasoralen
Ultramop
Uvadex
Xanthotoxin
XANTHOTOXIN

External Source Codes: 
CAS Registry Number 298-81-7 (see NLM ChemIDplus info)
FDA UNII Code U4VJ29L7BQ
ChEBI ID CHEBI:18358 (see ChEBI info)
NSC Code 45923 (see NCI DTP info)
PDQ Closed Trial Search ID 39499
PDQ Open Trial Search ID 39499 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025684

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cutaneous T-cell lymphoma; psoriasis; vitiligo
Chemical_Formula C12H8O4
code C643
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methoxsalen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C643

Mainbox Bottom