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Version: 16.11d (Release date: 2016-11-28)
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Asparaginase Erwinia chrysanthemi (Code C64260)

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Terms & Properties

Preferred Name: Asparaginase Erwinia chrysanthemi

Definition: An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation.

Display Name: Asparaginase Erwinia chrysanthemi

Label: Asparaginase Erwinia chrysanthemi

NCI Thesaurus Code: C64260 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0591457  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Asparaginase Erwinia chrysanthemi
ASPARAGINASE ERWINIA CHRYSANTHEMI
Crisantaspasum
Cristantaspase
Erwinase
Erwinaze
L-asparginase (Erwinia )

External Source Codes: 
CAS Registry Number 9015-68-3 (see NLM ChemIDplus info)
FDA UNII Code D733ET3F9O
NSC Code 106977 (see NCI DTP info)
PDQ Closed Trial Search ID 601044
PDQ Open Trial Search ID 601044 (check for NCI PDQ open clinical trial info)
UMLS CUI C0591457

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
code C64260
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Asparaginase-Erwinia
Semantic_Type Enzyme
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64260

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