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Version: 16.11d (Release date: 2016-11-28)
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Methotrexate (Code C642)

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Terms & Properties

Preferred Name: Methotrexate

Definition: An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

NCI-GLOSS Definition: A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite.

Display Name: Methotrexate

Label: Methotrexate

NCI Thesaurus Code: C642 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025677  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Amino-10-methylfolic Acid
4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid
Abitrexate
Alpha-Methopterin
Amethopterin
amethopterin
Brimexate
CL-14377
CL 14377
Emtexate
Emthexat
Emthexate
Farmitrexat
Fauldexato
Folex
Folex PFS
Lantarel
Ledertrexate
Lumexon
Maxtrex
Medsatrexate
Metex
Methoblastin
Methotrexate
METHOTREXATE
methotrexate
Methotrexate LPF
Methotrexate Methylaminopterin
Methotrexatum
Metotrexato
Metrotex
Mexate
Mexate-AQ
MTX
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid
Novatrex
Rheumatrex
Texate
Tremetex
Trexeron
Trixilem
WR-19039

External Source Codes: 
CAS Registry Number 59-05-2 (see NLM ChemIDplus info)
FDA UNII Code YL5FZ2Y5U1
ChEBI ID CHEBI:44185 (see ChEBI info)
NSC Code 740 (see NCI DTP info)
PDQ Closed Trial Search ID 41719
PDQ Open Trial Search ID 41719 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025677

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Abortion; Bladder cancer; Breast cancer; Carcinomatous; meningitis; Chorioadenoma destruens; Crohn's disease; Ectopic pregnancy; Esophageal cancer; Gestational choriocarcinoma
Accepted_Therapeutic_Use_For Graft versus host disease-prophylaxis; Head/neck cancer; Hydatidiform mole; Leukemia; meningeal; Lymphomas; Acute Lymphoblastic Leukemia; Burkitt's; Lung cancer; Mycosis fungoides; Osteosarcoma; Psoriasis; Rheumatoid arthritis; Wegener's granulomatosis
Chemical_Formula C20H22N8O5
code C642
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methotrexate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C642

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