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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Resiquimod (Code C63958)

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Terms & Properties

Preferred Name: Resiquimod

Definition: An imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity, this agent may potentially be useful as a vaccine adjuvant.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells. It is also being studied to find out if adding it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline and a type of immunomodulator.

Display Name: Resiquimod

Label: Resiquimod

NCI Thesaurus Code: C63958 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0389573  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
S 28463

External Source Codes: 
CAS Registry Number 144875-48-9 (see NLM ChemIDplus info)
ChEBI ID CHEBI:36706 (see ChEBI info)
PDQ Closed Trial Search ID 544217
PDQ Open Trial Search ID 544217 (check for NCI PDQ open clinical trial info)
UMLS CUI C0389573

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H22N4O2
code C63958
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Resiquimod
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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