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Version: 16.11d (Release date: 2016-11-28)
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Glucuronic Acid (Code C63810)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Glucuronic Acid

Definition: A carboxylic acid with structural similarity to glucose with detoxifying activity. The xenobiotic metabolism of various substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids involves glucuronidation, a process in which water-soluble, excretable glucuronides of these substances are formed via glycosidic linkages to glucuronic acid. UDP-glucuronic acid, formed in the liver through the linkage of glucuronic acid to uridine diphosphate (UDP) via a glycosidic bond, is an intermediate in the process of glucuronidation.

NCI-GLOSS Definition: A form of a type of sugar called glucose that helps remove harmful substances from the body. Glucuronic acid and the harmful substance combine in the liver and then are passed in the urine. Glucuronic acid is also found in other substances in the body, such as cartilage and synovial fluid (fluid found in the joints).

Label: Glucuronic Acid

NCI Thesaurus Code: C63810 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0061444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GLUCURONIC ACID
Glucuronic Acid
glucuronic acid

External Source Codes: 
CAS Registry Number 6556-12-3 (see NLM ChemIDplus info)
FDA UNII Code 8A5D83Q4RW
ChEBI ID CHEBI:4178 (see ChEBI info)
ChEBI ID CHEBI:47953 (see ChEBI info)
PDQ Closed Trial Search ID 663166
PDQ Open Trial Search ID 663166 (check for NCI PDQ open clinical trial info)
UMLS CUI C0061444

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6H10O7
code C63810
Contributing_Source FDA
Legacy_Concept_Name Glucuronic_Acid
Semantic_Type Chemical Viewed Structurally
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63810

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