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Version: 17.06d (Release date: 2017-06-26)
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Methadone Hydrochloride (Code C638)

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Terms & Properties

Preferred Name: Methadone Hydrochloride

Definition: The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of methadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate withdrawal symptoms are less severe.

NCI-GLOSS Definition: A drug used to treat moderate to severe pain that does not respond to other types of pain medicine. It is also used to help people who are addicted to opioid drugs such as heroin. Methadone hydrochloride binds to opioid receptors in the central nervous system. It is a type of analgesic agent and a type of opioid.

Display Name: Methadone Hydrochloride

Label: Methadone Hydrochloride

NCI Thesaurus Code: C638 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0721688  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adanon
Althose
Dolophine
Methadone Hydrochloride
methadone hydrochloride
METHADONE HYDROCHLORIDE
Methadose

External Source Codes: 
CAS Registry Number 1095-90-5 (see NLM ChemIDplus info)
FDA UNII Code 229809935B
ChEBI ID CHEBI:50140 (see ChEBI info)
NSC Code 19600 (see NCI DTP info)
PDQ Closed Trial Search ID 39498
PDQ Open Trial Search ID 39498 (check for NCI PDQ open clinical trial info)
UMLS CUI C0721688

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H27NO.HCl
code C638
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methadone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C638

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