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Version: 17.06d (Release date: 2017-06-26)
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Hydroxytyrosol (Code C63690)

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Terms & Properties

Preferred Name: Hydroxytyrosol

Definition: A phenolic phytochemical naturally occurring in extra virgin olive oil, with potential antioxidant, anti-inflammatory and cancer preventive activities. Although the mechanisms of action through which hydroxytyrosol exerts its effects have yet to be fully determined, this agent affects the expression of various components of the inflammatory response, possibly through the modulation of the nuclear factor-kappa B (NF-kB) pathway. The effects include the modulation of pro-inflammatory cytokines, such as the inhibition of interleukin-1alpha (IL-1a), IL-1beta, IL-6, IL-12, and tumor necrosis factor-alpha (TNF-a); increased secretion of the anti-inflammatory cytokine IL-10; inhibition of the production of certain chemokines, such as C-X-C motif chemokine ligand 10 (CXCL10/IP-10), C-C motif chemokine ligand 2 (CCL2/MCP-1), and macrophage inflammatory protein-1beta (CCL4/MIP-1b); and inhibition of the expression of the enzymes inducible nitric oxide synthase (iNOS/NOS2) and prostaglandin E2 synthase (PGES), which prevent the production of nitric oxide (NO) and prostaglandin E (PGE2), respectively. In addition, hydroxytyrosol is able to regulate the expression of other genes involved in the regulation of tumor cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases. Also, hydroxytyrosol scavenges free radicals and prevents oxidative DNA damage. This induces apoptosis and inhibits proliferation in susceptible cancer cells.

Label: Hydroxytyrosol

NCI Thesaurus Code: C63690 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0046981  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(3,4-Dihydroxyphenyl)ethanol
3,4-DHPEA
3,4-Dihydroxyphenylethanol
4-(2-Hydroxyethyl)-1,2-benzenediol
Hydroxytyrosol
HYDROXYTYROSOL

External Source Codes: 
CAS Registry Number 10597-60-1 (see NLM ChemIDplus info)
FDA UNII Code QEU0NE4O90
PDQ Closed Trial Search ID 758473
PDQ Open Trial Search ID 758473 (check for NCI PDQ open clinical trial info)
UMLS CUI C0046981

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H10O3
code C63690
Contributing_Source FDA
Legacy_Concept_Name _3_4-Dihydroxyphenylethanol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63690

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