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Version: 17.06d (Release date: 2017-06-26)
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Fresolimumab (Code C63546)

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Terms & Properties

Preferred Name: Fresolimumab

Definition: A pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity. Fresolimumab binds to and inhibits the activity of all isoforms of TGF-beta, which may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells.

NCI-GLOSS Definition: A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-TGF-beta monoclonal antibody GC1008 binds to the protein transforming growth factor-beta (TGF?) and may block the growth of cancer cells that make it.

Display Name: Fresolimumab

Label: Fresolimumab

NCI Thesaurus Code: C63546 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987643  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-TGF-beta monoclonal antibody GC1008
Anti-TGF-Beta Monoclonal Antibody GC1008
Fresolimumab
GC1008
Human Anti-TGF-Beta Monoclonal Antibody GC1008
Immunoglobulin G4, anti-(transforming growth factor beta) (human monoclonal GC-1008 heavy chain), disulfide with human monoclonal GC-1008 light chain, Dimer

External Source Codes: 
CAS Registry Number 948564-73-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 530302
PDQ Open Trial Search ID 530302 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987643

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, and cancer
code C63546
Contributing_Source CTRP
Legacy_Concept_Name Anti-TGF-Beta_Monoclonal_Antibody_GC1008
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63546

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