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Version: 17.06d (Release date: 2017-06-26)
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Minocycline-EDTA (Code C63545)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Minocycline-EDTA

Definition: A combination preparation containing minocycline, a broad-spectrum, semi-synthetic tetracycline antibiotic, and ethylenediaminetetraacetate (EDTA) with antimicrobial and anticoagulant activities. Minocycline exerts its bacteriostatic effect by binding to the bacterial 30S ribosomal subunit and preventing binding of aminoacyl-tRNA to the mRNA-ribosome complex during protein translation. This leads to an inhibition of bacterial protein synthesis and consequently interferes with cell growth. EDTA, a metal chelator, exerts its anticoagulant activity by binding to calcium, thereby impeding the activity of calcium-dependent coagulation proteins. This leads to an inhibition of thrombotic occlusion and prevention of bacterial colonization that could occur upon clot formation.

NCI-GLOSS Definition: A substance being studied in the treatment of bacterial infections from catheters (flexible tubes used to deliver fluids into or take fluids from the body). It combines a drug used to treat infections with a drug that prevents blood clots. It is a type of tetracycline antibiotic.

Display Name: Minocycline-EDTA

Label: Minocycline-EDTA

NCI Thesaurus Code: C63545 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831960  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
M-EDTA
Minocycline-EDTA
minocycline-EDTA
Minocycline-Ethylenediaminetetraacetate

External Source Codes: 
PDQ Closed Trial Search ID 509172
PDQ Open Trial Search ID 509172 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831960

Other Properties:
     Name Value (qualifiers indented underneath)
code C63545
Contributing_Source CTRP
Legacy_Concept_Name Minocycline-EDTA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63545

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