|Minocycline-EDTA (Code C63545)|
|Terms & Properties|
Preferred Name: Minocycline-EDTA
Definition: A combination preparation containing minocycline, a broad-spectrum, semi-synthetic tetracycline antibiotic, and ethylenediaminetetraacetate (EDTA) with antimicrobial and anticoagulant activities. Minocycline exerts its bacteriostatic effect by binding to the bacterial 30S ribosomal subunit and preventing binding of aminoacyl-tRNA to the mRNA-ribosome complex during protein translation. This leads to an inhibition of bacterial protein synthesis and consequently interferes with cell growth. EDTA, a metal chelator, exerts its anticoagulant activity by binding to calcium, thereby impeding the activity of calcium-dependent coagulation proteins. This leads to an inhibition of thrombotic occlusion and prevention of bacterial colonization that could occur upon clot formation.
NCI-GLOSS Definition: A substance being studied in the treatment of bacterial infections from catheters (flexible tubes used to deliver fluids into or take fluids from the body). It combines a drug used to treat infections with a drug that prevents blood clots. It is a type of tetracycline antibiotic.
Display Name: Minocycline-EDTA
NCI Metathesaurus Link: C1831960 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||509172|
|PDQ Open Trial Search ID||509172 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|