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Dextropropoxyphene Hydrochloride (Code C63538)

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Terms & Properties

Concept Status: Retired Concept  (See:  Propoxyphene Hydrochloride )

Preferred Name: Dextropropoxyphene Hydrochloride

Definition: The hydrochloride salt form of the d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain.

Label: Dextropropoxyphene Hydrochloride

NCI Thesaurus Code: C63538 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL415383  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dextropropoxyphene Hydrochloride

External Source Codes: 
NCI META CUI CL415383

Other Properties:
     Name Value (qualifiers indented underneath)
code C63538
Concept_Status Retired_Concept
deprecated true
DesignNote Wed Jan 12 15:12:12 EST 2011 - See 'Propoxyphene_Hydrochloride'
Legacy_Concept_Name Dextropropoxyphene_Hydrochloride
OLD_PARENT Opioid
OLD_PARENT Opioid_Receptor_Agonist
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63538

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