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Version: 17.06d (Release date: 2017-06-26)
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Fenretinide Lipid Matrix (Code C63482)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fenretinide Lipid Matrix

Definition: An orally bioavailable powder formulation of a synthetic phenylretinamide analogue of retinol with potential chemopreventive and antineoplastic activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types, including those of the colon, breast, prostate, and neuroblastoma. Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS). Compared to the capsule form, the powder contains a mixture of wheat flour, fats, and sugar that may contribute to the enhanced bioavailability of fenretinide.

NCI-GLOSS Definition: A powdered form of fenretinide that is being studied in the treatment of neuroblastoma. It may be used by the body more easily than the pill form. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.

Display Name: Fenretinide Lipid Matrix

Label: Fenretinide Lipid Matrix

NCI Thesaurus Code: C63482 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831747  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fenretinide Lipid Matrix
Fenretinide LXS
fenretinide LXS
Fenretinide Lym-X-Sorb
fenretinide Lym-X-Sorb

External Source Codes: 
PDQ Closed Trial Search ID 468556
PDQ Open Trial Search ID 468556 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831747

Other Properties:
     Name Value (qualifiers indented underneath)
code C63482
Contributing_Source CTRP
Legacy_Concept_Name Fenretinide_Lipid_Matrix
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63482

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