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Version: 17.06d (Release date: 2017-06-26)
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Oral Topotecan Hydrochloride (Code C63477)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Topotecan Hydrochloride

Definition: An oral formulation of the hydrochloride salt of topotecan, a semisynthetic derivative of the quinoline alkaloid camptothecin, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing topoisomerase I-DNA covalent complexes during the S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.

Display Name: Oral Topotecan Hydrochloride

Label: Oral Topotecan Hydrochloride

NCI Thesaurus Code: C63477 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831879  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'; 6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride
Oral Hycamtin
Oral Topotecan Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 489122
PDQ Open Trial Search ID 489122 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831879

Other Properties:
     Name Value (qualifiers indented underneath)
code C63477
Contributing_Source CTRP
Legacy_Concept_Name Oral_Topotecan_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C63477

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