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Version: 17.06d (Release date: 2017-06-26)
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Melphalan (Code C633)

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Terms & Properties

Preferred Name: Melphalan

Definition: A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

NCI-GLOSS Definition: A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.

Display Name: Melphalan

Label: Melphalan

NCI Thesaurus Code: C633 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025241  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[bis(2-chloroethyl)amino]-L-phenylalanine
Alanine Nitrogen Mustard
CB-3025
L-PAM
L-Phenylalanine mustard
L-Phenylalanine Mustard
L-Sarcolysin
L-sarcolysin
L-Sarcolysine
L-Sarcolysin Phenylalanine mustard
Melphalan
melphalan
MELPHALAN
Melphalanum
p-di(chloroethyl)amino-L-phenylalanine
Phenylalanine Mustard
Phenylalanine Nitrogen Mustard
Phenylalanine nitrogen mustard
Sarcoclorin
Sarkolysin
WR-19813

External Source Codes: 
CAS Registry Number 148-82-3 (see NLM ChemIDplus info)
FDA UNII Code Q41OR9510P
ChEBI ID CHEBI:28876 (see ChEBI info)
NSC Code 8806 (see NCI DTP info)
NSC Code 241286 (see NCI DTP info)
PDQ Closed Trial Search ID 42973
PDQ Open Trial Search ID 42973 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025241

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma
Chemical_Formula C13H18Cl2N2O2
code C633
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Melphalan
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C633

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