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Version: 17.06d (Release date: 2017-06-26)
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Medroxyprogesterone (Code C629)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Medroxyprogesterone

Definition: A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)

NCI-GLOSS Definition: A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.

Display Name: Medroxyprogesterone

Label: Medroxyprogesterone

NCI Thesaurus Code: C629 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025147  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
17Alpha-hydroxy-6alpha-methylprogesterone
6Alpha-methyl-17alpha-hydroxyprogesterone
6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione
Curretab
Medroxyprogesterone
MEDROXYPROGESTERONE
medroxyprogesterone

External Source Codes: 
CAS Registry Number 520-85-4 (see NLM ChemIDplus info)
FDA UNII Code HSU1C9YRES
ChEBI ID CHEBI:6715 (see ChEBI info)
NSC Code 27408 (see NCI DTP info)
PDQ Closed Trial Search ID 39813
PDQ Open Trial Search ID 39813 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025147

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast carcinoma; Contraception; Endometrial carcinoma; Renal cell carcinoma
Chemical_Formula C22H32O3
code C629
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Medroxyprogesterone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C629

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