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Version: 17.12d (Release date: 2017-12-26)
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Pegdinetanib (Code C62791)

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Terms & Properties

Preferred Name: Pegdinetanib

Definition: A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent.

Display Name: Pegdinetanib

Label: Pegdinetanib

NCI Thesaurus Code: C62791 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831965  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
VEGFR-2 inhibitor CT-322

External Source Codes: 
CAS Registry Number 906450-24-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 575516
PDQ Open Trial Search ID 575516 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831965

Other Properties:
     Name Value (qualifiers indented underneath)
code C62791
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CT-322
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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