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Version: 17.06d (Release date: 2017-06-26)
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Pegdinetanib (Code C62791)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pegdinetanib

Definition: A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent.

Display Name: Pegdinetanib

Label: Pegdinetanib

NCI Thesaurus Code: C62791 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831965  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Angiocept
BMS-844203
CT-322
Pegdinetanib
PEGDINETANIB
VEGFR-2 inhibitor CT-322

External Source Codes: 
CAS Registry Number 906450-24-6 (see NLM ChemIDplus info)
FDA UNII Code SSB56T0M0L
PDQ Closed Trial Search ID 575516
PDQ Open Trial Search ID 575516 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831965

Other Properties:
     Name Value (qualifiers indented underneath)
code C62791
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CT-322
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62791

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