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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Vinorelbine (Code C62790)

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Terms & Properties

Preferred Name: Liposomal Vinorelbine

Definition: A formulation of the semisynthetic vinca alkaloid, vinorelbine, encapsulated within liposomes, with antineoplastic activity. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in cell cycle arrest in metaphase. Like other vinca alkaloids, vinorelbine may also interfere with the metabolism of nucleic acids, lipids, amino acids, cAMP, and glutathione, as well as other biological processes including calmodulin-dependent Ca2+-transport, ATPase activity, or cellular respiration. Liposomal delivery of vinorelbine improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile.

Label: Liposomal Vinorelbine

NCI Thesaurus Code: C62790 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831959  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposomal Vinorelbine

External Source Codes: 
PDQ Closed Trial Search ID 507579
PDQ Open Trial Search ID 507579 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831959

Other Properties:
     Name Value (qualifiers indented underneath)
code C62790
Legacy_Concept_Name Liposomal_Vinorelbine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62790

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