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Version: 16.10e (Release date: 2016-10-31)
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5-Fluoro-2-Deoxycytidine (Code C62785)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 5-Fluoro-2-Deoxycytidine

Definition: An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It may prevent the growth of tumors by stopping cancer cells from dividing and by killing them. It is a type of antimetabolite.

Display Name: 5-Fluoro-2-Deoxycytidine

Label: 5-Fluoro-2-Deoxycytidine

NCI Thesaurus Code: C62785 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0049174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-FLUORO-2'-DEOXYCYTIDINE
5-Fluoro-2-Deoxycytidine
5-fluoro-2-deoxycytidine
Cytidine, 2'-deoxy-5-fluoro-
FdCyd
Ro 5-1090

External Source Codes: 
CAS Registry Number 10356-76-0 (see NLM ChemIDplus info)
FDA UNII Code KUA4693H5W
NSC Code 48006 (see NCI DTP info)
PDQ Closed Trial Search ID 509184
PDQ Open Trial Search ID 509184 (check for NCI PDQ open clinical trial info)
UMLS CUI C0049174

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C9H12FN3O4
code C62785
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _5-Fluoro-2-Deoxycytidine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62785

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