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Version: 17.06d (Release date: 2017-06-26)
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LMP2A-Specific Cytotoxic T-Lymphocytes (Code C62784)

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Terms & Properties

Preferred Name: LMP2A-Specific Cytotoxic T-Lymphocytes

Definition: A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity. T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation. EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas.

Label: LMP2A-Specific Cytotoxic T-Lymphocytes

NCI Thesaurus Code: C62784 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328049  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EBV-Specific Cytotoxic T-Lymphocytes
LMP2A-Specific CTL
LMP2A-Specific Cytotoxic T-Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 334454
PDQ Open Trial Search ID 334454 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328049

Other Properties:
     Name Value (qualifiers indented underneath)
code C62784
Legacy_Concept_Name LMP2A-Specific_Cytotoxic_T_Lymphocytes
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62784

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