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Version: 17.12d (Release date: 2017-12-26)
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Seliciclib (Code C62783)

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Terms & Properties

Preferred Name: Seliciclib

Definition: An orally available small molecule and cyclin-dependent kinase (CDK) inhibitor with potential apoptotic and antineoplastic activity. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Seliciclib primarily inhibits CDK 2, 7, and 9 by competing for the ATP binding sites on these kinases, leading to a disruption of cell cycle progression. In addition, this agent seems to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, thereby inhibiting RNA polymerase II-dependent transcription. This may lead to the down-regulation of anti-apoptotic factors, such as myeloid cell leukemia sequence 1 (Mcl-1), a protein crucial for the survival of a range of tumor cell types. The down-regulation of anti-apoptotic factors may lead to an induction of apoptosis, thereby further contributing to seliciclib's antiproliferative effects.

Display Name: Seliciclib

Label: Seliciclib

NCI Thesaurus Code: C62783 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1436187  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 186692-46-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 511023
PDQ Open Trial Search ID 511023 (check for NCI PDQ open clinical trial info)
UMLS CUI C1436187

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H26N6O
code C62783
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Seliciclib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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