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Version: 17.06d (Release date: 2017-06-26)
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Seliciclib (Code C62783)

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Terms & Properties

Preferred Name: Seliciclib

Definition: An orally available small molecule and cyclin-dependent kinase (CDK) inhibitor with potential apoptotic and antineoplastic activity. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Seliciclib primarily inhibits CDK 2, 7, and 9 by competing for the ATP binding sites on these kinases, leading to a disruption of cell cycle progression. In addition, this agent seems to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, thereby inhibiting RNA polymerase II-dependent transcription. This may lead to the down-regulation of anti-apoptotic factors, such as myeloid cell leukemia sequence 1 (Mcl-1), a protein crucial for the survival of a range of tumor cell types. The down-regulation of anti-apoptotic factors may lead to an induction of apoptosis, thereby further contributing to seliciclib's antiproliferative effects.

Display Name: Seliciclib

Label: Seliciclib

NCI Thesaurus Code: C62783 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1436187  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CYC202
R-roscovitine
Seliciclib
SELICICLIB

External Source Codes: 
CAS Registry Number 186692-46-6 (see NLM ChemIDplus info)
FDA UNII Code 0ES1C2KQ94
PDQ Closed Trial Search ID 511023
PDQ Open Trial Search ID 511023 (check for NCI PDQ open clinical trial info)
UMLS CUI C1436187

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H26N6O
code C62783
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Seliciclib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62783

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