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Version: 17.06d (Release date: 2017-06-26)
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Obatoclax Mesylate (Code C62771)

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Terms & Properties

Preferred Name: Obatoclax Mesylate

Definition: The mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It is a form of obatoclax, which blocks the activity of certain proteins needed for cells to live and may cause tumor cells to die. It is a type of apoptosis inducer.

Display Name: Obatoclax Mesylate

Label: Obatoclax Mesylate

NCI Thesaurus Code: C62771 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831948  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-3-methoxy-2H-pyrrol-5-yl)-1H-indole Monomethanesulfonate
GX15-070MS
Obatoclax Mesylate
obatoclax mesylate
OBATOCLAX MESYLATE

External Source Codes: 
CAS Registry Number 803712-79-0 (see NLM ChemIDplus info)
FDA UNII Code 39200FJ43J
PDQ Closed Trial Search ID 504100
PDQ Open Trial Search ID 504100 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831948

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H19N3O.CH4O3S
code C62771
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Obatoclax_Mesylate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62771

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