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Version: 16.11d (Release date: 2016-11-28)
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Nintedanib (Code C62765)

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Terms & Properties

Preferred Name: Nintedanib

Definition: An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. In addition, this agent also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (fms-like tyrosine kinase 3). VEGFR, FGFR and PDGFR RTKs play key roles in tumor angiogenesis.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. BIBF 1120 blocks enzymes needed for cells to grow, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Nintedanib

Label: Nintedanib

NCI Thesaurus Code: C62765 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2930789  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BIBF-1120
BIBF 1120
Intedanib
Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Multitargeted Tyrosine Kinase Inhibitor BIBF 1120
Nintedanib
NINTEDANIB
tyrosine kinase inhibitor BIBF 1120
Vargatef

External Source Codes: 
CAS Registry Number 656247-17-5 (see NLM ChemIDplus info)
FDA UNII Code G6HRD2P839
PDQ Closed Trial Search ID 504524
PDQ Open Trial Search ID 504524 (check for NCI PDQ open clinical trial info)
UMLS CUI C2930789

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C31H33N5O4
code C62765
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BIBF_1120
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62765

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