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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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PM00104 (Code C62763)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PM00104

Definition: A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential antineoplastic activity. PM00104 reversibly binds to DNA, thereby inducing cytotoxicity due to its interference with DNA replication, transcription, and translation processes. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 demonstrates a manageable and reversible cytotoxicity as part of its antitumor activity.

Display Name: PM00104

Label: PM00104

NCI Thesaurus Code: C62763 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1568937  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PM00104
Zalypsis

External Source Codes: 
PDQ Closed Trial Search ID 502184
PDQ Open Trial Search ID 502184 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 19584237 (see PubMed Primary Reference info)
UMLS CUI C1568937

Other Properties:
     Name Value (qualifiers indented underneath)
code C62763
Contributing_Source CTRP
Legacy_Concept_Name PM00104
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62763

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