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Version: 17.06d (Release date: 2017-06-26)
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Mechlorethamine Hydrochloride (Code C627)

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Terms & Properties

Preferred Name: Mechlorethamine Hydrochloride

Definition: The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.

NCI-GLOSS Definition: A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell's DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent.

Display Name: Mechlorethamine Hydrochloride

Label: Mechlorethamine Hydrochloride

NCI Thesaurus Code: C627 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0600266  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bis(2-chloroethyl)methylamine Hydrochloride
Chlorethamine HCl
chlorethamine hydrochloride
Chlorethazine Hydrochloride
Chlormethine Hydrochloride
Chlormethine hydrochloride
Chloromethine HCl
Chloromethine Hydrochloride
ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride
HN 2 Hydrochloride
mechlorethamine HCl
Mechlorethamine Hydrochloride
mechlorethamine hydrochloride
Mechlorethamine hydrochloride
Methylbis(beta-chloroethyl)amine Hydrochloride
Methylchlorethamine Hydrochloride
Mustargen HCl
Mustargen hydrochloride
Mustargen Hydrochloride
Mustine hydrochloride
Mustine Hydrochloride

External Source Codes: 
CAS Registry Number 55-86-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:55368 (see ChEBI info)
NSC Code 762 (see NCI DTP info)
PDQ Closed Trial Search ID 43434
PDQ Open Trial Search ID 43434 (check for NCI PDQ open clinical trial info)
UMLS CUI C0600266

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bronchogenic carcinoma; chronic lymphocytic and myelcytic leukemia; Hodgkins dieseas, palliative; lymphosarcoma; mycosis fungoides; polycythemia vera
Chemical_Formula C5H11Cl2N.HCl
code C627
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Nitrogen_Mustard
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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