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Version: 17.06d (Release date: 2017-06-26)
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Maytansine (Code C626)

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Terms & Properties

Preferred Name: Maytansine

Definition: An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)

Label: Maytansine

NCI Thesaurus Code: C626 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0024975  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione
Alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9, 22-diazatetracyclo[,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione
L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]
L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8, 23-dioxo-4,24-dioxa-9,22-diazatetracyclo[,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*, 3R*,5R*,6R*,16E,18E,20S*,21R*)]-

External Source Codes: 
CAS Registry Number 35846-53-8 (see NLM ChemIDplus info)
FDA UNII Code 14083FR882
NSC Code 153858 (see NCI DTP info)
PDQ Closed Trial Search ID 39492
PDQ Open Trial Search ID 39492 (check for NCI PDQ open clinical trial info)
UMLS CUI C0024975

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H46ClN3O10
code C626
Contributing_Source FDA
Legacy_Concept_Name Maytansine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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