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Version: 17.06d (Release date: 2017-06-26)
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CHP-NY-ESO-1 Peptide Vaccine IMF-001 (Code C62598)

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Terms & Properties

Preferred Name: CHP-NY-ESO-1 Peptide Vaccine IMF-001

Definition: A peptide cancer vaccine containing nanoparticles of cholesteryl hydrophobized pullulan (CHP) complexed with the cancer-testis antigen NY-ESO-1 protein, with potential immunostimulating and antineoplastic activities. Upon administration, CHP-NY-ESO-1 peptide vaccine IMF-001 may stimulate the host immune system to mount a humoral and cytotoxic T-cell response against tumor cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis. The self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms stable colloidal nanoparticles in water. NY-ESO-1, an antigen found in normal testis, is upregulated in various cancers, including bladder, breast, hepatocellular, melanoma, and prostate cancers.

Display Name: CHP-NY-ESO-1 Peptide Vaccine IMF-001

Label: CHP-NY-ESO-1 Peptide Vaccine IMF-001

NCI Thesaurus Code: C62598 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831881  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cholesteryl Pullulan-NY-ESO-1 Vaccine IMF-001
CHP-NY-ESO-1 Peptide Vaccine IMF-001
IMF-001

External Source Codes: 
PDQ Closed Trial Search ID 489132
PDQ Open Trial Search ID 489132 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831881

Other Properties:
     Name Value (qualifiers indented underneath)
code C62598
Contributing_Source CTRP
Legacy_Concept_Name CHP-NY-ESO-1_Peptide_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62598

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