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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Parathyroid Hormone (Code C62555)

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Terms & Properties

Preferred Name: Recombinant Parathyroid Hormone

Definition: A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain a constant concentration of calcium ions (Ca2+) in the extracellular fluid. In target tissues, parathyroid hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled receptor; there are two types of receptors, PTHR1 found in bone and the kidney and PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta. Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase C in target tissue cells, which, depending upon the specific target tissue, results in the enhancement of intestinal Ca2+ absorption, mobilization of bone Ca2+, and renal Ca2+ reabsorption.

Display Name: Recombinant Parathyroid Hormone

Label: Recombinant Parathyroid Hormone

NCI Thesaurus Code: C62555 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1882913  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PARATHYROID HORMONE
Recombinant Parathyroid Hormone

External Source Codes: 
CAS Registry Number 9002-64-6 (see NLM ChemIDplus info)
FDA UNII Code N19A0T0E5J
PDQ Closed Trial Search ID 489119
PDQ Open Trial Search ID 489119 (check for NCI PDQ open clinical trial info)
UMLS CUI C1882913

Other Properties:
     Name Value (qualifiers indented underneath)
code C62555
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Parathyroid_Hormone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62555

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