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Version: 16.11d (Release date: 2016-11-28)
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14C BMS-275183 (Code C62553)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 14C BMS-275183

Definition: An orally bioavailable taxane compound, a C-4 methyl carbonate analogue of paclitaxel, labeled with radioactive carbon 14, with potential antineoplastic and radioimaging activities. BMS-275183 binds to tubulin and as a result inhibits microtubule disassembly or assembly. This leads to cell cycle arrest at the G2/M phase, thereby resulting in an inhibition of cell division and ultimately cell death. BMS-275183 may be useful for treating multi-drug resistant tumors as it does not appear to be a substrate for P-glycoprotein.

Label: 14C BMS-275183

NCI Thesaurus Code: C62553 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831856  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
14C BMS-275183
[14C] BMS-275183

External Source Codes: 
PDQ Closed Trial Search ID 487486
PDQ Open Trial Search ID 487486 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831856

Other Properties:
Name Value (qualifiers indented underneath)
code C62553
Legacy_Concept_Name _14C_BMS-275183
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62553

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