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Version: 17.12d (Release date: 2017-12-26)
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Glutathione Disulfide NOV-002 (Code C62537)

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Terms & Properties

Preferred Name: Glutathione Disulfide NOV-002

Definition: A stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, glutathione disulfide NOV-002 acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis; S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by a glutathione disulfide NOV-002-induced increase in GGT activity. Glutathione disulfide NOV-002 may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo.

Display Name: Glutathione Disulfide NOV-002

Label: Glutathione Disulfide NOV-002

NCI Thesaurus Code: C62537 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1138321  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glutathione Disulfide NOV-002
Oxidized Glutathione NOV-002

External Source Codes: 
PDQ Closed Trial Search ID 494994
PDQ Open Trial Search ID 494994 (check for NCI PDQ open clinical trial info)
UMLS CUI C1138321

Other Properties:
     Name Value (qualifiers indented underneath)
code C62537
Contributing_Source CTRP
Legacy_Concept_Name NOV-002
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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